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Alex Dayton Selected Research

(3,5- bis((4- fluorophenyl)methylidene)- 1- ((1- hydroxy- 2,2,5,5- tetramethyl- 2,5- dihydro- 1H- pyrrol- 3- yl)methyl)piperidin- 4- one)

11/2011HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.
11/2011Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867.
11/2010Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties.
9/2010HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.
5/2010Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.

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Alex Dayton Research Topics

Disease

6Neoplasms (Cancer)
01/2019 - 05/2010
3Hypertension (High Blood Pressure)
01/2019 - 01/2016
2Carcinoma (Carcinomatosis)
11/2011 - 09/2010
2Ovarian Neoplasms (Ovarian Cancer)
11/2011 - 09/2010
1Type 2 Diabetes Mellitus (MODY)
01/2019
1Albuminuria
02/2016
1Cardiotoxicity
11/2011
1Prostatic Neoplasms (Prostate Cancer)
05/2010
1Substance-Related Disorders (Drug Abuse)
07/2009

Drug/Important Bio-Agent (IBA)

5(3,5- bis((4- fluorophenyl)methylidene)- 1- ((1- hydroxy- 2,2,5,5- tetramethyl- 2,5- dihydro- 1H- pyrrol- 3- yl)methyl)piperidin- 4- one)IBA
11/2011 - 05/2010
3SaltsIBA
01/2019 - 01/2016
2AntioxidantsIBA
11/2011 - 05/2010
1PotassiumIBA
01/2019
1TOR Serine-Threonine KinasesIBA
01/2019
1PP242IBA
01/2019
1Mechanistic Target of Rapamycin Complex 1IBA
01/2019
1Mechanistic Target of Rapamycin Complex 2IBA
01/2019
1Sirolimus (Rapamycin)FDA Link
01/2019
1SodiumIBA
01/2019
1RNA (Ribonucleic Acid)IBA
02/2016
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
02/2016
1NADP (NADPH)IBA
02/2016
1Oxidoreductases (Dehydrogenase)IBA
02/2016
1Pharmaceutical PreparationsIBA
11/2011
1Doxorubicin (Adriamycin)FDA LinkGeneric
11/2011
1CurcuminIBA
11/2011
1Cisplatin (Platino)FDA LinkGeneric
11/2011
1Proteins (Proteins, Gene)FDA Link
09/2010
1Messenger RNA (mRNA)IBA
09/2010
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
09/2010
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
09/2010
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2010
1Mitogen-Activated Protein Kinase 3IBA
09/2010
1Focal Adhesion Protein-Tyrosine KinasesIBA
09/2010
1Sterol Regulatory Element Binding Protein 1IBA
09/2010
1ErbB Receptors (EGF Receptor)IBA
09/2010
1PiperidonesIBA
05/2010
1Caspase 3 (Caspase-3)IBA
05/2010
1Superoxides (Superoxide)IBA
05/2010
1Antineoplastic Agents (Antineoplastics)IBA
05/2010
1Hydroxylamine (Hydroxylamine Hydrochloride)IBA
05/2010
1nitroxylIBA
05/2010
1alpha,beta-diacryloxypropionic acid (DAPS)IBA
05/2010

Therapy/Procedure

4Therapeutics
11/2011 - 07/2009
1Drug Therapy (Chemotherapy)
11/2011
1Injections
11/2011